All applets, scripts and plug-ins (including PDF and PowerPoint files, etc.) and the content within them are accessible to assistive technologies, or else an alternative means of accessing equivalent content is provided.
A PDF file can be made accessible to screen reader users, but it may be best to include an accessible HTML version of a document instead of or in addition to PDF.
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Learn more about creating Accessible PDFs by reading Adobe's PDF Accessibility Overview
Create and verify PDF accessibility (Acrobat Pro): Acrobat tools make it easy to create accessible PDFs and check the accessibility of existing PDFs. You can create PDFs to meet common accessibility standards, such as Web Content Accessibility Guidelines (WCAG) 2.0 and PDF/UA (Universal Access, or ISO 14289). The simple, guided workflow lets you do the following:
Make PDFs accessible: A predefined action automates many tasks, checks accessibility, and provides instructions for items that require manual fixes. Quickly find and fix problem areas.
Check accessibility: The Full Check/Accessibility Check tool verifies whether the document conforms to accessibility standards, such as PDF/UA and WCAG 2.0.
Report accessibility status: The Accessibility Report summarizes the findings of the accessibility check. It contains links to tools and documentation that assist in fixing problems.